Early Life Exposure to Manure-Fertilized Soil Shapes the Gut Antibiotic Resistome.

ABSTRACT: The global rise of antimicrobial resistance (AMR) presents a pressing public health challenge with agricultural practices such as the use of manure fertilization, excessive antibiotic use in livestock, and the irrigation of crops with contaminated water contributing to the spread of antibiotic resistance genes (ARGs). Despite growing concerns, the pathways through which ARGs migrate from environmental reservoirs to animal microbiomes are poorly understood. In this study, we raised mice from birth in pig manure-fertilized red (Ultisols) and black (Mollisols) soils or unfertilized controls, sampling their gut microbiomes at 8 weeks, to show that early life exposure to manure-fertilized soil profoundly shapes the gut antibiotic resistome in mice. Application of organic manure significantly en

SUBMITTER: Zhai ZQ 

PROVIDER: S-EPMC12362212 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature