Biannual Mass Azithromycin Distributions for Preschool Children and Malaria Parasitemia: A Secondary Analysis of the MORDOR Cluster Randomized Trial.

ABSTRACT:

Importance

Mass azithromycin distributions may reduce malaria parasitemia in the short term, but longer-term effectiveness is unclear.

Objective

To examine whether biannual mass azithromycin distributions are associated with lower rates of malaria parasitemia in preschool children living in Niger.

Design, setting, and participants

A cluster randomized trial was performed from November 23, 2014, until June 9, 2020, as an ancillary trial to a larger trial studying the effect of mass azithromycin on child mortality. Study communities (ie, government-defined health catchment areas) in Niger were randomized in a 1:1 ratio to biannual (ie, twice-yearly) mass administration of azithromycin or placebo to all children aged 1 to 59 months and followed up for 5 years. Data analy

SUBMITTER: Arzika AM 

PROVIDER: S-EPMC12362227 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature