Strontium/magnesium-doped coralline hydroxyapatite for bone regeneration.

ABSTRACT: The biocompatibility, osteoconductivity and porous structure of coral make it a popular material for bone regeneration. However, coral mismatches host bone degradation rates and lacks osteoinductivity. No prior research has investigated the physicochemical properties of strontium-doped coralline hydroxyapatite (Sr-CHA), magnesium-doped (Mg-CHA) and strontium- and magnesium-co-doped (Sr-Mg-CHA), especially their osteogenic mechanisms. This study synthesized CHA doped with osteoinductive elements (Sr, Mg and Sr-Mg) via a hydrothermal reaction to preserve 26.5-33.5% of the unconverted inner core of calcium carbonate (CaCO3). Under identical reaction circumstances, the Sr doping ratio in the Sr-CHA outperformed Mg in the Mg-CHA. In contrast, Sr and Mg mutually inhibit each other during co-dopi

SUBMITTER: Chen B 

PROVIDER: S-EPMC12362243 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature