Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos.

ABSTRACT:

Importance

Chlorpyrifos (CPF) is one of the most widely used insecticides throughout the world. Preclinical and clinical studies have suggested that prenatal CPF exposure is neurotoxic, but its effects on the human brain are unknown.

Objective

To identify the associations of prenatal CPF exposure with brain structure, function, and metabolism in school-aged children.

Design, setting, and participants

This prospective, longitudinal pregnancy cohort study was conducted from January 1998 to July 2015, with data analysis from February 2018 to November 2024 in a community in northern Manhattan and South Bronx, New York. Of 727 pregnant women of African American or Dominican descent in the original community cohort, 512 had CPF levels measured at delivery. Offspring 6 years

SUBMITTER: Peterson BS 

PROVIDER: S-EPMC12362277 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature