Dopaminergic Modulation of Short-Term Associative Memory in Caenorhabditis elegans.

ABSTRACT: Forgetting, the inability to retrieve previously encoded memories, is an active process involving neurotransmission, second messenger signalling and cytoskeletal modifications. Forgetting is thought to be essential to remove irrelevant memories and to increase the capacity to encode new memories. Therefore, identifying key regulators of active forgetting is crucial to advance our understanding of neuroplasticity. In this study, we utilised the compact and tractable Caenorhabditis elegans model to investigate the role of the neurotransmitter dopamine in forgetting. We conducted butanone associative learning assays based on an established protocol and used mutant strains deficient in dopamine synthesis (tyrosine hydroxylase CAT-2 and dopamine transporter DAT-1) and signalling (G protein-coup

SUBMITTER: McMillen A 

PROVIDER: S-EPMC12362331 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature