Safety of having a subsequent pregnancy after prior diagnosis of breast cancer during pregnancy in young BRCA carriers.

ABSTRACT:

Background

For women carrying a germline pathogenic or likely pathogenic variant in the BRCA1/2 genes, having a pregnancy following breast cancer diagnosis and treatment is safe. However, no evidence exists on the safety of having a subsequent pregnancy in BRCA carriers with a prior diagnosis of breast cancer during pregnancy (PrBC).

Methods

The BRCA BCY Collaboration (NCT03673306) is an international, multicenter, retrospective cohort study that included BRCA carriers diagnosed with invasive breast cancer at the age ≤40 years between January 2000 and December 2020. This analysis included only women diagnosed with PrBC comparing patients who had a subsequent pregnancy to those without. Primary endpoints were the cumulative incidence of having a subsequent pregnancy and disea

SUBMITTER: Perachino M 

PROVIDER: S-EPMC12362513 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature