Inherent Weakly Coordinating Oxo-Group-Directed Ruthenium(II)-Catalyzed C5 Functionalization of 2-Arylquinolin-4(1<i>H</i>)-ones.

ABSTRACT: A Ru(II)-catalyzed inherent weakly coordinating oxo-group-directed site-selective C5 functionalization of 2-arylquinolin-4(1H)-ones using various coupling partners like allyl alcohols, acrylates, styrenes, maleimides, and acrylamide has been described. The developed method allowed the synthesis of C5-substituted 2-arylquinolin-4(1H)-ones in good to excellent yields. The protocol is compatible with a broad range of functional groups and can be used on the gram scale. In addition, based on the control experiments, a plausible reaction mechanism has been proposed for this transformation.

SUBMITTER: Jangir T 

PROVIDER: S-EPMC12362596 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature