Engineering Cell Fate with Adaptive Feedback Control.

ABSTRACT: Engineering cell fate is fundamental to optimizing therapies based on stem cells, which are aimed at replacing cells in patients suffering from trauma or disease. By timely administering molecular regulators (e.g., transcription factors, RNAs, or small molecules) in a process that mimics in vivo embryonic development, stem cell differentiation can be guided toward a specific cell fate. However, scaling up these therapies is extremely challenging because such differentiation strategies often result in mixed cellular populations. While synthetic biology approaches have been proposed to increase the yield of desired cell types, designing gene circuits that effectively redirect cell fate decisions requires mechanistic insight into the dynamics of the endogenous regulatory networks that govern

SUBMITTER: Britto Bisso F 

PROVIDER: S-EPMC12362612 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature