Hyaluronic Acid-Decorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis.

ABSTRACT: Nanotechnology allows drugs to be delivered locally and specific cells to be targeted, leading to a promising new therapeutic approach for interstitial lung fibrosis. Hyaluronic acid (HA)-decorated imatinib-loaded liposomes (LIP-HA44700-Im) are developed to target CD44 positive cells for the inhalation treatment of fibrogenic lung disorders. LIP-HA44700-Im are assessed for their uptake and biological activity on respiratory effectors that are related to CD44 expression and compared to undecorated liposomes (LIP). LIP-HA44700-Im uptake is significantly higher than that of LIP, and most of the internalized LIP-HA44700-Im are colocalized with cellular endosomes. LIP-HA44700-Im also reduce lung fibroblasts viability. After 24 h, LIP-HA44700-Im are able to impair collagen 1a1 release and c-Abl

SUBMITTER: Bozzini S 

PROVIDER: S-EPMC12362731 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature