Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding.

ABSTRACT: The innate immune response is crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). Yet, the roles of eosinophils in TMJOA remain unclear, underscoring the need for further investigation into their potential impact and mechanism. Addressing the clinical observation that eosinophil numbers in synovial fluid are higher in healthy individuals than in those with TMJOA, the vital regulation of this cell population in TMJOA by using an ovalbumin (OVA)-induced hyper-eosinophilia asthma rats is explored and a rat model of antibody-mediated eosinophil depletion in vivo, and co-culture system of synovial fibroblasts, chondrocytes, and eosinophils in vitro. The abnormal synovial proliferation, cartilage degradation, and subchondral bone erosion are effectively inhibited in OVA

SUBMITTER: Chen W 

PROVIDER: S-EPMC12362735 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature