Mitochondria-Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation.

ABSTRACT: Periodontitis is a chronic inflammatory disease characterized by hypoxia, excessive oxidative stress, and immune dysregulation, leading to tissue destruction and bone resorption. Although antioxidants can reduce ROS and inflammation, most lack specificity and have a short residence time, limiting their effectiveness. Since mitochondria are the primary source of ROS, targeting mitochondrial ROS is a promising strategy for periodontitis treatment. However, this alone cannot address the complex "ROS-inflammation-hypoxia" cycle in periodontitis, requiring a more comprehensive approach. Here, a natural enzyme cascade nanogel (TPP-SAT) composed of triphenylphosphine (TPP), superoxide dismutase (SOD), and catalase (CAT) via in-situ polymerization is developed. TPP-SAT targets mitochondrial ROS, c

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC12362747 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature