Nano-Anesthetics Regulate Neuro-Immune Interaction for Treating Neuropathic Pain.

ABSTRACT: Neuropathic pain is a multifaceted syndrome posing significant challenges to patient quality of life and healthcare systems. Conventional treatments primarily focus on general pain modulation, which fail to address specific underlying mechanisms, leading to limited efficacy and infinite side effects. Calcitonin gene-related peptide (CGRP) has played a pivotal role in neuro-immune repair, contributing to vasodilation, nociception, and immune modulation following tissue injury. Herein, a bupivacaine-loaded cerium-based metal-organic framework (CUB) is designed to integrate sustained release of analgesia with immunomodulatory and antioxidant capabilities. In vivo models of chronic constriction injury (CCI) have demonstrated that CUB significantly reduced neuroinflammation, promoted M2 microgl

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12362777 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature