Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke.

ABSTRACT: Neural stem cell therapies hold great promise for improving stroke recovery, but the hostile stroke microenvironment can hinder the initial graft survival. It has long been well documented that the microenvironment evolves over time, making it crucial to identify the optimal transplantation window to maximize therapeutic efficacy. However, it remains uncertain whether acute or delayed local cell transplantations better supports graft viability after stroke. Here, it is shown that delayed intracerebral transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent cells (iPSCs) at 7 days post stroke significantly enhances graft proliferation and survival, and promotes axonal sprouting, compared to acute transplantation at 1 day post stroke, in a mouse model of larg

SUBMITTER: Weber RZ 

PROVIDER: S-EPMC12362810 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature