Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4-Mediated Ferritinophagy Associated with Cisplatin-Induced Hearing Loss.

ABSTRACT: Cisplatin can cause irreversible hearing loss. However, effective approaches to its prevention are not established. In this study, the effect of the traditional Chinese medicine monomer pinoresinol diglucoside (PDG) is evaluated on cisplatin-induced ototoxicity and its underlying mechanism of action. PDG significantly increases cell viability and inhibits reactive oxygen species production and ferroptosis in cisplatin-treated House Ear Institute-Organ of Corti 1 cells and basilar membranes. PDG partially restores hearing loss caused by cisplatin. Transcriptome sequencing identifies Suppressor of Cytokine Signaling 1 (SOCS1), which is significantly elevated in the cisplatin-only group but significantly reduced after PDG application. SOCS1 is a ferroptosis-promoting factor, and knocking it d

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12362821 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature