Dysregulated lipid metabolism in kidney stone pathogenesis: a literature review of mechanistic insights and therapeutic implications.

ABSTRACT: Kidney stone disease (KSD) is a globally prevalent urinary system disorder whose pathogenesis involves complex interactions among metabolic, genetic, and environmental factors. Although the role of glucose metabolism in KSD has been widely studied, the impact of lipid metabolism abnormalities remains unclear. This review systematically integrates epidemiological, animal model, and molecular mechanism studies to explore the mechanisms by which lipid metabolism disorders promote KSD through key regulatory factors, such as peroxisome proliferator-activated receptors (PPARs), fatty acid-binding proteins (FABPs), and apolipoproteins, synergizing with organelle damage pathways, including mitochondrial dysfunction, endoplasmic reticulum stress (ERS), and ferroptosis.This study revealed that abnor

SUBMITTER: Wen Q 

PROVIDER: S-EPMC12362858 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature