Food-derived extracellular vesicles for treatment of osteoporosis: a systematic review and meta-analysis of preclinical animal studies.

ABSTRACT:

Objective

Food-derived extracellular vesicles (EVs) are considered a novel therapeutic approach for osteoporosis. However, their efficacy in treating osteoporosis remains unclear. This systematic review and meta-analysis aim to preliminarily evaluate and explore the effects of food-derived EVs in animal models of osteoporosis.

Methods

PubMed, Embase, and Web of Science databases were searched for preclinical studies on food-derived EVs in the treatment of osteoporosis, up to November 25, 2024. A meta-analysis was conducted to evaluate the effects of food-derived EVs on bone mineral density (BMD), bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation/marrow thickness (Tb.Sp), trabecular number (Tb.N), and serum bone turnover markers in osteopor

SUBMITTER: Shi H 

PROVIDER: S-EPMC12362866 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature