The role of the striatin family proteins in hippo signaling and cellular regulation.

ABSTRACT: The striatin family proteins, striatin, SG2NA, and zinedin, belong to the calmodulin-binding WD-40 repeat protein group and are components of the striatin interacting phosphatase and kinase (STRIPAK) complex. These proteins are known for their roles as scaffold proteins, facilitating various cellular pathways, and regulating cell-cell interactions and signaling mechanisms. The observation that Striatin is expressed in cell junctions, suggests a potential role in maintaining cell integrity and communication. Here, we used shRNA technology to examine the biological significance of the striatin family proteins. This approach allowed us to modulate their expression levels and observe the effects on cellular processes. Our results suggest that the striatin family members affect the Hippo signal

SUBMITTER: Shor-Nareznoy Y 

PROVIDER: S-EPMC12362926 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature