Association between the triglyceride to high-density lipoprotein cholesterol ratio and diabetes mellitus likelihood in patients with chronic kidney disease.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) are at an increased risk of diabetes mellitus (DM) and dyslipidemia, yet the specific relationship between lipid profiles, particularly triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C ratio), and DM likelihood in this population has not been thoroughly elucidated.

Methods

We conducted a cross-sectional analysis of 20,310 unselected patients with CKD enrolled from 2006 to 2015. The relationship between the TG/HDL-C ratio and the likelihood of DM was evaluated using binary logistic regression. Sensitivity and subgroup analyses were performed, and a generalized additive model with smooth curve fitting assessed potential non-linear associations. We also performed the receiver operating characteristic (ROC

SUBMITTER: Guan M 

PROVIDER: S-EPMC12362956 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature