Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia.

ABSTRACT:

Background

Antipsychotic-induced movement disorders (AIMDs) are prevalent side effects of antipsychotics, particularly during the acute phase of treatment. This study aimed to elucidate the genetic mechanisms underlying AIMDs using a genome-wide association study (GWAS).

Methods

GWASs on AIMDs were conducted in 3 independent cohorts: a discovery cohort of 3067 patients (2016 subjects were reserved after quality control), a validation cohort of 277 patients, and a multi-ancestry validation cohort of 766 patients. Subsequent post-GWAS analyses included gene-based analyses, transcriptome-wide association studies (TWASs), and polygenic risk score (PRS) profiling.

Results

Our study identified 2 loci located in RAB44 gene (rs116249243, P = 5.98 × 10^-9; rs11709748

SUBMITTER: Lu Z 

PROVIDER: S-EPMC12362978 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature