GeneRiskCalc: a web-based tool for genetic risk association analysis in case-control studies.

ABSTRACT:

Background

Genetic association studies play a pivotal role in identifying disease-associated variants, but researchers face challenges in performing essential calculations like Hardy-Weinberg equilibrium testing, odds ratios, and confidence intervals due to reliance on manual methods or multiple software tools. We aimed to develop GeneRiskCalc, an integrated web-based platform that simplifies genetic association analysis by automating Hardy-Weinberg equilibrium assessment, odds ratios with confidence interval calculation, and visual data presentation in case-control studies. Using an HTML/CSS/JavaScript framework, we developed online software with three core functionalities: (1) automated HWE evaluation, (2) odds ratio with 95% confidence interval computation with statistical valid

SUBMITTER: Sudershan A 

PROVIDER: S-EPMC12363000 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature