Genetic characteristics of rotavirus a in Shenzhen and Zhuhai, China, 2020-2023.

ABSTRACT:

Background

Rotavirus A group (RVA) is a leading cause of viral diarrhea, posing a substantial economic and public health burden. Compared to other enteric viruses, RVA possesses diverse genetic mechanisms, making it more challenging to control and prevent. Moreover, surveillance and evolutionary studies on RVA remain limited in Southern China.

Methods

We collected diarrheal stool samples from sentinel hospitals in Shenzhen and Zhuhai between 2020 and 2023. RVA-positive samples were identified via RT-PCR, followed by RNA extraction, sequencing, and genome assembly, yielding 57 RVA strains, comprising 604 sequences. Genotype trends were analyzed statistically. For phylogenetic analysis, global sequences were curated by CD-HIT, aligned with contributed sequences by MAFFT, and a

SUBMITTER: Hu M 

PROVIDER: S-EPMC12363023 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature