Associations of perfluoroalkyl substances (PFAS) with terminal ductal lobular unit involution of the normal breast.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) may be carcinogenic, and animal studies demonstrate their harmful effects on mammary gland development. Terminal ductal lobular units (TDLUs) are the structures that produce milk following childbirth, and involution of TDLUs normally occurs with aging. Most breast cancers arise from TDLUs, and a greater degree of TDLU involution may be associated with lower breast cancer risk. We estimated associations between PFAS concentrations and TDLU involution in normal breast tissue samples.

Methods

Concentrations of seven PFAS were measured in serum provided by a subset of 263 cancer-free volunteer participants from the Susan G. Komen for the Cure Tissue Bank (KTB) who were postmenopausal, not currently using hormone therapy, and

SUBMITTER: Reeves KW 

PROVIDER: S-EPMC12363039 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature