The protective role of ureteral stents in reducing fibrosis and preventing stricture in ureteral injuries of different severities.

ABSTRACT:

Purpose

Ureteral injuries following endoscopic interventions often lead to fibrosis and subsequent stricture formation, yet the optimal use and duration of ureteral stents in preventing these outcomes remain unclear. This study aimed to determine whether ureteral stents have an inhibitory effect on fibrosis development and provide evidence to optimize stent use and duration.

Methods

This study was conducted between March and October 2023. Rabbit models with varying degrees of ureteral injury (G1-G4) were established according to the Post-Ureteroscopy Lesion Scale (PULS), dividing into Control (no ureteral stent placement), 2-week (stent placed for 2 weeks), and 4-week (stent placed for 4 weeks) groups. Ureteral tissues from G1-G4 models were collected at 2- and 4-weeks post-

SUBMITTER: Gu H 

PROVIDER: S-EPMC12363042 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature