Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes.

ABSTRACT:

Background

Heme oxygenase 1 (HO-1), encoded by the HMOX1 gene is a highly inducible enzyme with multiple cardiovascular protective properties. Polymorphisms of the HMOX1 gene, especially a guanine-thymine dinucleotide repeat polymorphism (GTn), affects its transcriptional activity and is associated with cardiovascular complications in the general population. We studied the association of HMOX1 polymorphisms and HO-1 serum concentrations with vascular complications and all-cause mortality in individuals with type 1 diabetes (T1D).

Methods

The study population consists of individuals with T1D participating in the Finnish Diabetic Nephropathy Study (FinnDiane). We genotyped the HMOX1 GTn repeat (n = 3990), extracted from genome-wide genotyping data two single nucleotide polymor

SUBMITTER: Segersvard H 

PROVIDER: S-EPMC12363068 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature