Cold-inducible RNA-binding protein is associated with subtype-specific breast cancer patient outcomes.

ABSTRACT:

Background

Cold-inducible RNA-binding protein (CIRBP) is a stress-induced mRNA-binding protein associated with clinical outcomes in a variety of human disease states. The role of CIRBP as a role as a prognostic biomarker in breast cancer (BC) has yet to be established.

Findings

We describe a clinically annotated tissue micro-array cohort of 1406 hormone receptor positive (HR +) and 281 triple negative primary breast cancers (TNBC) stained by immunohistochemistry (IHC) for CIRBP. Statistical analyses were performed with the Kaplan-Meier estimator, as well as univariate and multivariate Cox proportional-hazards models. Multivariate models incorporated tumor size, lymph node status, grade and CIRBP expression levels. Co-primary endpoints were overall survival (OS) and progressi

SUBMITTER: Dankner M 

PROVIDER: S-EPMC12363121 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature