Global burden, temporal trends, and health workforce correlations of gallbladder and biliary tract cancer: a comprehensive analysis from 1990 to 2021 with projections to 2046.

ABSTRACT:

Background

Gallbladder and biliary tract cancers (GBTCs) represent aggressive malignancies with poor prognosis and rising global incidence. While previous studies have examined disease burden patterns, the relationship between health workforce capacity and GBTC outcomes remains unexplored, representing a critical knowledge gap in understanding healthcare system determinants of disease management effectiveness.

Methods

We conducted a comprehensive epidemiological analysis using Global Burden of Disease Study 2021 data from 204 countries and territories (1990-2021). Age-standardized rates and absolute numbers for incidence, prevalence, mortality, and disability-adjusted life years were analyzed. Advanced statistical approaches included age-period-cohort modeling, decomposition

SUBMITTER: Dai F 

PROVIDER: S-EPMC12363135 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature