Radiomic features of infrapatellar fat pad are associated with knee symptoms and radiographic post-traumatic osteoarthritis at 10+ years after anterior cruciate ligament reconstruction.

ABSTRACT: The infrapatellar fat pad (IPFP) has been identified as a potential agent in joint degeneration leading to post-traumatic osteoarthritis (PTOA) in patients suffering from anterior cruciate ligament (ACL) injury. We leveraged machine learning and radiomics methods on knee MRI taken at ten-year follow-up post-ACL reconstruction to associate IPFP with knee symptoms and radiographic PTOA. In this cross-sectional study, the multi-site NIH-funded MOON nested Onsite cohort was followed up at ten years to obtain 3D MRI radiomics and patient-reported outcome measures (PROM). We identified the features with two radiomics-based classifiers that can detect, respectively, knee symptoms based on PROM data or radiographic PTOA based on Kellgren-Lawrence grade. We identified 29 radiomics features describi

SUBMITTER: Khan S 

PROVIDER: S-EPMC12363159 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature