Pseudorabies virus induces natural killer cell depletion by GSDMD-mediated inflammation and pyroptosis to promote infection and lung injury.

ABSTRACT: Pseudorabies virus (PRV) infection induces a hyperinflammatory response to promote inflammatory injury in multiple tissues. However, the relative mechanism remains elusive. Herein, we first confirmed that PRV infection could trigger pyroptosis to cause lung injury, evidenced by the increased release of pro-inflammatory cytokines and lactate dehydrogenase (LDH) in lung tissue of infected piglets and mice. Subsequently, we observed that PRV-induced lung lesions and mortality were improved in Gsdmd^-/- mice rather than in Ripk3^-/- mice. The number of NK cells was markedly higher in Gsdmd^-/- mice than in WT mice. Based on this finding, refilling NK cells could significantly alleviate the replication of PRV in the lungs of mice and alleviate

SUBMITTER: Chen J 

PROVIDER: S-EPMC12363163 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature