Epstein-Barr virus-infected tonsillar marginal zone B cells <i>in vivo</i> as a precursor for immunosuppression-related B-cell lymphoma.

ABSTRACT: The germinal center model (GCM) of Epstein-Barr virus (EBV) persistence in humans proposes that EBV infects and drives naïve B cells through the GC to establish a quiescent lifelong persistent infection in memory B cells. EBV causes several cancers, and the normal in vivo counterparts of major EBV-associated cancers have been identified in the GCM. Yet, the normal in vivo counterparts of immunosuppression-related/immunoblastic B-cell lymphoma (IL), which occurs in immunosuppressed transplant and HIV patients and resembles lymphoblastoid cell lines (LCLs), remain elusive. We performed a comparative analysis of human tonsillar B cells to identify the closest normal in vivo counterparts of ILs/LCLs. Here we show that EBV-infected tonsillar marginal zone (MZ) B cells, whic

SUBMITTER: Torgbor C 

PROVIDER: S-EPMC12363164 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature