High genomic stability of Andes virus following successive passage <i>in vivo</i> in Syrian hamsters.

ABSTRACT: Andes virus (ANDV) is a South American hantavirus that causes hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory infection with a case fatality rate as high as 40%. A critical model for studying HCPS is the Syrian hamster model, which faithfully recapitulates key aspects of the disease. Recent studies have shown that strains of ANDV from different origins, i.e., from rodent or human hosts, can produce widely different outcomes in the hamster model. CHI-7913, a human isolate, does not cause lethal disease and replicates poorly in hamster tissues compared with the classical rodent isolate Chile-9717869. Here, we passaged CHI-7913 in vivo in Syrian hamsters 25 times and infected groups of hamsters with virus from passages 2, 12, and 24 to assess whether viral adaptation o

SUBMITTER: Warner BM 

PROVIDER: S-EPMC12363185 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature