<i>Streptococcus salivarius</i>-derived ilexgenin A alleviates pneumonia through the gut-lung axis.

ABSTRACT: The alteration of gut microbiota during critical illness is associated with adverse clinical outcomes. This connection between intestinal dysbiosis and poor outcomes has prompted the idea that restoring healthy microbial communities could offer a novel approach to life-support treatment for patients with severe pneumonia. In this study, using 16S rRNA sequencing and fecal microbiota transplantation (FMT), we demonstrated that alterations in intestinal microbiota structure during pneumonia exacerbate disease outcomes. A notable feature of these alterations is the reduction in the relative levels of Streptococcus salivarius (S. salivarius). In combination with metabolomics analysis, we found that the administration of S. salivarius increased the level of ilexgenin A (IA)

SUBMITTER: Huang X 

PROVIDER: S-EPMC12363194 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature