Breadth of antibody activity elicited by an influenza B hemagglutinin vaccine is influenced by pre-existing immune responses to influenza B viruses.

ABSTRACT: Most people are exposed to influenza A and influenza B viruses (IBV) at an early age through natural infection or vaccination. These previous exposures can shape future immune responses and the ability to either recall memory B cells or generate de novo immune responses. Therefore, it is important to consider pre-existing immunity when testing vaccine candidates. The B/Victoria (B/VIC) and the B/Yamagata (B/YAM) lineages circulated in the human population between 1987 and 2020 until the B/YAM lineage stopped circulating following the coronavirus disease 2019 pandemic. Most people born prior to 2020 have pre-existing immune responses to both lineages of IBV. Therefore, in this report, the impact of vaccine-induced antibodies was explored in mice with pre-existing immune responses to

SUBMITTER: Carlock MA 

PROVIDER: S-EPMC12363200 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature