Predictors of Bi-directional Transitions From Mild Cognitive Impairment in a Diverse Cohort.

ABSTRACT: Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic and racial groups, social factors, medical comorbidities, and biases in assessment procedures may contribute to greater heterogeneity in the MCI diagnostic category and affect its prognostic significance for dementia. The study goal was to evaluate the frequency and variables associated with MCI transitions among non-Hispanic White (NHW) and Latinx older adults. Multistate Markov models characterized transitions across diagnostic states (cognitively unimpaired (CU), MCI, dementia) over ten years. Variables associated with transitions were assessed using hazard ratios (HR) and 95% confidence intervals (CIs). The study included 413 participants (58% female, mean

SUBMITTER: Gonzales MM 

PROVIDER: S-EPMC12363215 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature