Targeting papillomavirus infections: high-throughput screening reveals an effective inhibitor of cutaneous β-HPV types.

ABSTRACT: Cutaneous and mucosal human papillomaviruses (HPVs) are implicated in the development of various cancers. To date, there are no HPV-specific antivirals, and vaccines designed for mucosal HPV types are ineffective against cutaneous HPV variants and ongoing infections. These facts, along with the increasing prevalence of specific types of HPV-positive cancers, underscore the unmet need for HPV antiviral drugs. In this study, we performed a high-throughput screening using the National Cancer Institute Diversity Set VI library of small-molecule compounds and identified 5,7-dimethoxy-2-pyridin-3-ylchromen-4-one (NSC51349) as a potent inhibitor of oncogenic cutaneous HPV5 replication in U2OS cells. Further analysis showed that NSC51349 specifically inhibits replication of the HPV5 genome in huma

SUBMITTER: Ibragimov R 

PROVIDER: S-EPMC12363231 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature