3D-printed weight holders design and testing in mouse models of spinal cord injury.

ABSTRACT: This paper details the comprehensive design and prototyping of a 3D-printed wearable device tailored for mouse models which addresses the need for non-invasive applications in spinal cord studies and therapeutic treatments. Our work was prompted by the increasing demand for wearable devices in preclinical research on freely behaving rodent models of spinal cord injury. We present an innovative solution that employs compliant 3D-printed structures for stable device placement on the backs of both healthy and spinal cord-injured mice. In our trial, the device was represented by two magnets that applied passive magnetic stimulation to the injury site. This device was designed to be combined with the use of magnetic nanoparticles to render neurons or neural cells sensitive to an exogenous magne

SUBMITTER: De Vincentiis S 

PROVIDER: S-EPMC12363281 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature