Prevalence of Celiac Disease in Patients With Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.

ABSTRACT: Celiac disease (CeD) has been linked to both autoimmunity and chronic liver disease, but most data on the link to primary biliary cholangitis (PBC) originate from small studies and have yielded conflicting results. A systematic search was performed in the databases of Medline, Embase, Cochrane and Web of Science Core Collection for studies published between 1990 and 2024, using search terms related to CeD, gluten and PBC. The search identified 2016 publications, of which 94 were read in full text. Of these, a total of 25 studies were included in this review, with 22 deemed relevant for meta-analysis. We applied a random effects model to estimate the weighted pooled prevalence along with corresponding 95% confidence intervals (CIs). Results were reported in accordance with the PRISMA guidel

SUBMITTER: Zingone F 

PROVIDER: S-EPMC12363381 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature