Bovine Endometrium Drives and Responds to Divergence of In Vitro Produced Conceptus Biochemistry.

ABSTRACT: In vitro produced (IVP) bovine embryos enhance herd genetics for important food production traits and support advanced reproductive technologies. However, less than 50% survive the first month of gestation after transfer to the surrogate. While the biochemical consequences of in vitro culture on the embryo before transfer have been well documented, less is known after transfer when the embryo interacts with the endometrium and pregnancy failure occurs. To investigate crosstalk between the IVP and in vivo derived (IVD) bovine conceptus and endometrium, a Day 16 conceptus-endometrial mono-culture and co-culture system was used, integrating transcriptomic and proteomic analyses. The IVP conceptus transcriptome (differentially expressed genes; DEG) diverged from the IVD conceptus but only afte

SUBMITTER: Peterson KD 

PROVIDER: S-EPMC12363384 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature