The Current Landscape of Repurposed Drugs for Fungal Neglected Tropical Diseases.

ABSTRACT: Eumycetoma, chromoblastomycosis, and sporotrichosis are three of only four fungal infections recognized as Neglected Tropical Diseases (NTDs) by the World Health Organization. They are a significant source of morbidity in subtropical and tropical regions of the Americas, Africa, and Asia. There are very few treatments approved for these diseases. Clinicians often use drug repurposing, off-label use of existing drugs, for their treatment. This article is a systematic review of the published literature on the treatment of fungal NTDs from the last five years (2019-2024). It will provide an overview for each fungal NTD, their current treatment landscape, and the challenges associated with their treatment. Itraconazole remains the most widely used antifungal for the treatment of these fungal N

SUBMITTER: Farid T 

PROVIDER: S-EPMC12363401 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature