Breaking Bonds by Light: The Absorbance-Fragmentation Paradox.

ABSTRACT: Multi-branched probes based on 2-hydroxymethylene 8-dimethylaminoquinoline (8-DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near-infrared two-photon (2P) activation conditions. While octupolar (3) and quadrupolar (2) DMAQ derivatives showed superior ε and 2P absorption cross-section (σ₂) values relative to the dipolar (1) probe, the fragmentation efficiency exhibited an inverse correlation with the enhanced absorption. Compound 1 emerged as the most effective probe reported to date for the release of organic substrates under both UV and 2P activation conditions at wavelengths accessible to commercially available lasers, achieving a quantum yield (Q) of 12% with σ₂ = 86 GM and uncaging cross-section δ_u = 10.2 GM a

SUBMITTER: Dunkel P 

PROVIDER: S-EPMC12363429 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature