Supragingival microbial profiles in caries-free and caries-active adolescents treated with fixed orthodontics.

ABSTRACT: Dental caries occur primarily due to the formation of excessive dental plaque biofilm on teeth surfaces. This study aims to analyze the supragingival microbial profiles of permanent teeth in caries-free and caries-active adolescents with fixed orthodontic appliances and to identify bacterial biomarkers that may be indicative of caries activity in specific population. Twelve-year-old adolescents treated with fixed orthodontic appliances were selected as the study population, with 5 caries-free and 5 caries-active subjects. Supragingival plaque samples were collected from the first permanent molars for the 16S rRNA high-throughput sequencing analysis of the V3-V4 region. There was no significant difference in alpha diversity and beta diversity between the caries-free and caries-active groups

SUBMITTER: Miao X 

PROVIDER: S-EPMC12363470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature