Intratumorally specific microbial-derived lipopolysaccharide contributes to non-small cell lung cancer progression.

ABSTRACT: As an emerging component of the tumor microenvironment (TME), the intratumoural microbiota imperceptibly influences the progression of various human malignancies. However, the critical intratumoural microbiota and its role in non-small cell lung cancer (NSCLC) progression have not been fully elucidated. Here, we used high-throughput sequencing and clinical samples analysis to identify the relationship between intratumoural bacteria and NSCLC progression. The results showed that significant abnormalities in the intratumoural microbiota of NSCLC. Specifically, the relative abundance of gram-negative bacteria in tumor was significantly increased, and network analysis revealed that Escherichia-Shigella and unclassified_f__Enterobacteriaceae, which have strong abilities to synthes

SUBMITTER: Sha G 

PROVIDER: S-EPMC12363524 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature