Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the <i>All of Us</i> Research Program.

ABSTRACT:

Importance

Over seven million U.S. adults experience "long COVID", or persistent health issues after COVID-19. Multiple guidelines recommend the inclusion of functional status in long COVID diagnostic criteria, but more evidence is needed to guide this recommendation. This study explores the adjusted odds of developing long COVID by pre-infection symptoms and functional status, and the feasibility of estimating functional status using health records data. DESIGN: Retrospective cohort study in a multicenter national longitudinal cohort of U.S. adults with history of COVID-19, using health records and survey responses through July 2022 (All of Us CDR 7.0).

Exposures

Pre-infection (-5 years) incidences of (a) at least one symptom common in long COVID, and (b) functional

SUBMITTER: Kehl-Floberg K 

PROVIDER: S-EPMC12363706 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature