Characterizing the informativeness of pathogen genome sequence datasets about transmission between population groups.

ABSTRACT: Pathogen genome analysis helps characterize transmission between population groups. The information carried by pathogen sequences comes from the accumulation of mutations within their genomes; thus, that the pace at which mutations accumulate should determine the granularity of transmission processes that pathogen sequences can characterize. Here, we investigate how the complex interplay between mutation, transmission, population mixing and sampling impacts the power of phylogeographic studies. First, we develop a conceptual probabilistic framework to quantify the ability of pairs of sequences in capturing migration history. This allows us to comprehensively explore the space of possible phylogeographic analyses by explicitly considering the pace at which mutations accumulate and the pace

SUBMITTER: Tran-Kiem C 

PROVIDER: S-EPMC12363720 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature