Intracortical microstimulation in humans: a decade of safety and efficacy.

ABSTRACT:

Background

Intracortical microstimulation (ICMS) of somatosensory cortex can restore a sense of touch to people with spinal cord injury (SCI). In this early-feasibility clinical trial, we evaluate the safety, efficacy, and longevity of ICMS as there is a paucity of such long-term studies in humans. This information is crucial to the development of clinical neuromodulation devices, particularly for restoring touch, hearing, and vision.

Methods

ICMS was delivered to five participants with SCI who were each implanted with two Blackrock NeuroPort microelectrode arrays in the hand representation of Brodmann's Area 1. Across implant durations spanning two to ten years, we measured single-electrode detection thresholds, projected fields, quality reports, and electrode health charac

SUBMITTER: Greenspon CM 

PROVIDER: S-EPMC12363726 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature