HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry.

ABSTRACT:

Aims/hypothesis

Type 1 diabetes is characterized by the destruction of pancreatic beta cells. Genetic factors account for ~50% of the total risk, with variants in the Human Leukocyte Antigen (HLA) region contributing to half of this genetic risk, with research historically focused on populations of European ancestry. We developed HLA-focused type 1 diabetes genetic risk scores (T1D GRS_HLA) utilizing single nucleotide polymorphisms (SNPs) or HLA alleles from four ancestry groups (Admixed African (AFR; T1D GRS_HLA-AFR), Admixed American (AMR; T1D GRS_HLA-AMR), European (EUR; T1D GRS_HLA-EUR), Finnish (FIN; T1D GRS_HLA-FIN) and across ancestry (ALL; T1D GRS_HLA-ALL). We assessed the performance of genetic risk scores in each

SUBMITTER: Michalek DA 

PROVIDER: S-EPMC12363735 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature