Emotional Processing After Severe Traumatic Brain Injury: Insights from Functional MRI and Pupillometry.

ABSTRACT:

Objective

Emotional dysfunction is a common consequence of severe traumatic brain injury (TBI), yet the mechanisms underlying these symptoms remain poorly understood. This study investigated whether brain network and autonomic mechanisms involved in emotional processing are abnormal in TBI.

Methods

We conducted a cross-sectional study of chronic severe TBI (n=26) and healthy control participants (n=15). We analysed functional MRI (fMRI) data to assess brain processing of emotionally salient music (joyful and fearful stimuli; n=15 TBI, n=15 controls), and resting-state fMRI (rsfMRI) to measure the functional connectivity of relevant intrinsic brain networks (limbic, salience, and default mode networks; n=16 TBI, n=15 controls). We additionally measured the pupillary light ref

SUBMITTER: Kazazian K 

PROVIDER: S-EPMC12363739 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature