Pathogenic germline variants in a racially diverse real-world cohort of prostate cancer patients.

ABSTRACT:

Importance

Pathogenic germline variant (PGV) rates in cancer risk genes and their association with clinical pathological features inform genetic testing practices for prostate cancer (PCa) patients.

Objective

To determine the rate of PCa risk gene PGVs in a real-world, diverse cohort of PCa patients and identify clinical predictors of carrier status.

Design setting participants main outcomes and measures

Genetic testing results for 12 PCa risk genes, clinical, pathological, and family history of cancer variables were abstracted from clinical records for 1032 PCa patients who met National Comprehensive Cancer Network (NCCN) genetic testing criteria in oncology clinics and 3602 PCa patients who underwent testing in the VA National Precision Oncology Program (VA-NPOP). I

SUBMITTER: Crawford TB 

PROVIDER: S-EPMC12363747 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature