V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery.

ABSTRACT:

Purpose

To develop a computational model that addresses limitations in current ocular irritation assessment methods, particularly regarding long-term effects, and recovery patterns following chemical exposure or trauma to the cornea.

Methods

V-Cornea is an agent-based computer simulation implemented in CompuCell3D that models corneal epithelial homeostasis and injury response. The model incorporates biologically-inspired rules governing cell behaviors (proliferation, differentiation, death) and key signaling pathways including Epidermal Growth Factor (EGF), translating cell-level behaviors to tissue-level outcomes (in vitro to in vivo extrapolation, IVIVE).

Results

V-Cornea successfully reproduces corneal epithelial architecture and maintains tissue home

SUBMITTER: Vanin J 

PROVIDER: S-EPMC12363777 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature