Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth.

ABSTRACT: Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its tissue-specific regulation and systemic physiological roles remain poorly understood. Here, using Drosophila melanogaster , we uncover a gut-renal circuit in which dietary VB5 stimulates CoA biosynthesis specifically in the Malpighian tubules (MTs, the fly kidney), non-autonomously impacting gut homeostasis. We show that Myc boosts renal CoA production by directly upregulating Fbl ( PANK1-3 homolog) and downregulating dPANK4 in the MTs. Elevated CoA biosynthesis enhances the mevalonate-isoprenoid pathway activity in the gut, promoting intestinal stem cell proliferation.

SUBMITTER: Miao T 

PROVIDER: S-EPMC12363785 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature