Genome-wide mapping of cyclic AMP receptor protein binding in Enteroaggregative <i>Escherichia coli</i> reveals targeting of virulence-associated genes.

ABSTRACT: Bacterial pathogens use a wide array of virulence factors to colonise and subsequently elicit disease in their host. These factors are often subject to extensive regulation at the transcriptional level, to ensure that their expression is timely. Although many pathogens use bespoke transcription factors that primarily target virulence genes, global transcription factors also sometimes play a role in controlling these genes. Enteroaggregative Escherichia coli (EAEC) is a significant cause of watery and mucoid diarrhoea globally. The organism colonises the small intestine before producing toxins that elicit disease, using a multitude of virulence factors that are encoded both chromosomally and on virulence plasmids. In this work, we have studied the cAMP Receptor Protein (CRP), a well-

SUBMITTER: Alhammadi MM 

PROVIDER: S-EPMC12363807 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature